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ea0032oc5.5 | Reproduction | ECE2013

FSHB −211 and FSHR 2039 polymorphisms are associated with serum levels of FSH, AMH and age of pubertal onset in 78 healthy girls: a longitudinal cohort study

Hagen Casper P , Aksglaede Lise , Sorensen Kaspar , Mouritsen Annette , Mieritz Mikkel G , Main Katharina M , Almstrup Kristian , Rajpert-De Meyts Ewa , Anderson Richard A , Juul Anders

Context: Potency of the FSH-pathway varies according to polymorphisms in the promoter of the gene encoding the FSH beta subunit (FSHB −211 G>T, rs10835638) and in the gene encoding the FSH receptor (FSHR 2039 A>G, rs6166). A recent study suggested that carriers of the combination of FSHB GG and FSHR AA had the most reproductive fit phenotype (higher serum FSH and a more sensitive FSH receptor). In pre-pubertal girls...

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Endocrine Abstracts

FSHB −211 and FSHR 2039 polymorphisms are associated with serum levels of FSH, AMH and age of pubertal onset in 78 healthy girls: a longitudinal cohort study

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